Ocular biomarkers for neurodegenerative and systemic disease

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Ocular biomarkers for neurodegenerative and systemic disease.

The eye is a readily accessible window to the brain and the retina has been proven to reveal presymptomatic evidence of brain disorders and systemic diseases, including Alzheimer disease, stroke and diabetes. Here we describe three approaches we are taking to examine the utility of retinal imaging for age-onset diseases. Alzheimer disease develops slowly, with “plaques” of amyloidbuilding up in...

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Alzheimer's Disease and Glaucoma: Imaging the Biomarkers of Neurodegenerative Disease

Imaging through the visual system in Alzheimer's disease, with the technology currently in widespread use for the diagnosis and management of eye disease such as glaucoma and macular degeneration, is proving to be promising. In vivo cross-section imaging during an annual comprehensive eye exam has been available for a decade for glaucoma and macular degeneration, and this same imaging, using Op...

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Ocular Manifestations of Systemic Disease

Diabetes Mellitus is most commonly manifested as fast developing cataracts. This type of cataract is the result of increased glucose in the aqueous humor. The cataract often has a prominent Y suture line on the anterior portion of the lens, making it the “Yes” for diabetes. Blood glucose is recommended for diagnosis. In fact 85% of all diabetic dogs will develop cataracts within 18 months of di...

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Can MRI screen for CSF biomarkers in neurodegenerative disease?

OBJECTIVE Alzheimer disease (AD) and frontotemporal lobar degeneration (FTLD) may have overlapping clinical presentations despite distinct underlying neuropathologies, thus making in vivo diagnosis challenging. In this study, we evaluate the utility of MRI as a noninvasive screening procedure for the differential diagnosis of AD and FTLD. METHODS We recruited 185 patients with a clinically di...

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Behcet's Disease: Systemic and Ocular Manifestations

AIM The aim of this study was to evaluate if patients with Behcet's disease who have ocular involvement have a more severe form of this disease as compared to patients with Behcet's disease alone. METHODS A total of 99 patients were included in the study. 76 patients were used as part of the examined group, and 23 patients formed a control group. RESULTS The following are the results of exa...

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ژورنال

عنوان ژورنال: Medical Journal of Australia

سال: 2014

ISSN: 0025-729X,1326-5377

DOI: 10.5694/mja14.00924